Cushing’s Control™
A powerful herbal blend for horses with Cushing’s disease (PPID), metabolic syndrome, insulin resistance, endocrine issues, and metabolic concerns.
PITUITARY pars intermedia dysfunction (PPID, Cushing’s disease) is a progressive neurodegenerative disease. Normally, dopamine binds to the pituitary receptors, regulating hormone levels. However, with horses suffering Cushing’s disease, a neuronal impairment leads to hormone imbalances that can severely affect their quality of life.
Equine Cushing’s disease can affect horses of any age (2.9% of all horses) but is most prevalent in those aged 15 and older where it has been reported to affect around 20% of horses. Any breed may develop the disease, and increasing age is the only identified significant risk factor.
While Cushing’s disease, equine metabolic syndrome, and insulin resistance are not considered curable, they can be managed, along with a diet high in fiber and fat and low in sugar and starch, a good senior grain with an eye to reduced sugars and carbohydrates, plenty of water, good living conditions, stress management, and responsible exercise.
Cushing’s Control™ is designed to provide endocrine and metabolic support, blood sugar control, and bolster and balance the adrenal system. This allows the symptomatic healing these horses require with an additional adaptogen action to reduce a horse’s stress and autonomic stress reactions. The remarkable chia seed is a low glycemic but power-packed nutraceutical in itself.
Cushing’s Control™ is affordable, safe, easy to use, delicious and will not test positive for any banned substances should your horse still be competing! Like our Jeremiah’s Ulcer Repulser™, there are no fillers not expressly needed by horses struggling with these health challenges.
These conditions, when properly attended to, need some time to reflect improvement, but most do improve very-noticeably with Cushing’s Control™. As the weeks pass, your old friend should experience a marked recovery and return to a more normal lifestyle and activity.
Most horses love the taste, just sprinkle over the AM and PM feeding, and yes, this can be used alongside Jeremiah’s Ulcer Repulser™. Horses experiencing other metabolic issues too have found great results with Cushing’s Control™. Poorly functioning pituitary and adrenals can burden the thyroid tremendously, help one and help the other, help the entire horse.
Chaste tree berries (Vitex agnus-castus). Chaste tree berries support healthy pituitary function in horses with Cushing’s disease (PPID). Their diterpenes and flavonoids influence dopaminergic signaling, helping regulate prolactin and overall hormone balance. Enhanced dopaminergic activity is associated with improved coat shedding, better haircoat condition, reduced excessive sweating, drinking, and urination, and a brighter, more alert attitude.
They also provide antioxidant support, helping limit oxidative stress linked with chronic endocrine imbalance. Glucose and insulin regulation may also be supported, though responses vary between horses.
Chia Seeds (Salvia hispanica). Chia seeds form a mucilaginous gel in the digestive tract, slowing carbohydrate digestion and supporting more stable blood glucose levels. The gel also increases bulk and lubricity in the gut, assisting in the passage of sand and fine debris and reducing the risk of colic.
Low in starch and non-structural carbohydrates, chia seeds are rich in high-quality protein, antioxidants, flavonoids, and omega-3 fatty acids (ALA). They provide 18 of the 22 amino acids required by horses, including all nine essential amino acids, supporting healthy inflammatory response, immune function, skin, hooves, and coat condition.
Chia seeds are also a valuable source of B vitamins and minerals, including calcium, phosphorus, magnesium, potassium, iron, zinc, and copper. Magnesium supports insulin regulation and neuromuscular function, while omega-3s help maintain normal cell-membrane sensitivity to insulin. Dry chia seeds can absorb many times their weight in water, aiding hydration.
Rhodiola root (Rhodiola rosea). Rhodiola root is a powerful adaptogen that enhances resilience to stress and fatigue. Its active compounds, rosavins and salidroside, support stress-response pathways, promoting steady energy, mental clarity, and vitality.
In horses, Rhodiola supports sustained energy, endurance, and a calmer, more focused demeanor, particularly in those experiencing PPID-related fatigue or mood changes. It also provides antioxidant and immune-supportive benefits and may contribute to healthy glucose regulation, making it an important component of metabolic support.
Siberian ginseng (Eleutherococcus senticosus). Siberian ginseng is an adaptogenic herb that supports energy, stamina, and mental alertness while reducing the effects of stress. It promotes a calmer, more focused demeanor, aiding horses with fatigue or mood shifts associated with PPID.
It also enhances immune function, recovery after physical activity, and antioxidant protection, helping maintain overall wellness. By supporting balanced stress-response pathways, Siberian ginseng is a key ingredient in comprehensive support programs for performance, endurance, and age-related endocrine changes.
Probiotics. A blend of Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus plantarum helps establish a healthy intestinal microbiome. These probiotics support digestive balance, nutrient absorption, and overall gut health, which is particularly valuable for horses with PPID or digestive sensitivities.
L-Glutamine (vegetarian). L-Glutamine replenishes amino acid stores depleted during metabolic stress, providing fuel for muscles and immune cells. It supports tissue repair, protects against illness, and contributes to overall gut and immune health — important for horses with chronic endocrine conditions.
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